Dr. Joseph M. Miller DO - ROOT Cause Supplements, LLC

https://drjosephmillerobgyn.com

An animal study found semaglutide reduced lean mass by about 10%, with the liver shrinking nearly in half and skeletal muscles losing 6% of their size. In a clinical trial of 140 adults, semaglutide users lost about 15 pounds of lean muscle over 68 weeks.

As with everything it comes down to Risks and Benefits, GLP-1 agents have many benefits, however, simply recognize the risks such as loss of excess lean muscle mass, and decreased bone density. My recommendation would be to take a "Drug Holiday" which is a term used in the medical literature. For example, every 6 months take a 2 month break.